Argos is a webcomic about a lesbian college student, Lena de Leon, who is struggling with finding herself and her purpose in life. She meets Mandy, a peppy vet student, and is immediately enamored but struggles with anxiety and self-doubt in forming a new relationship and her fear of ruining their friendship. 

Everything changes when she finds an abandoned puppy, whom she names Argos, and he pushes her towards finding a new goal in life and gaining the self-confidence she needs to pursue those goals.